I suspect the only useful power boost one could give the Bugatti engines, assuming they were stressed for it, would be supercharging or turbo-supercharging (most likely the former unless you were going for alititude performance). For simplicity's sake, I rather like the idea of a Hispano 12Y driving a simple three-bladed prop as you can make the prop gearbox stronger when you don't have to worry about contra-rotating props (fewer gears mean to fit the volume means you can make the individual components more robust). I wonder, though, if a 16-cylinder equivalent of the 12Y was available and would fit?
I'd like to know more about the Miller engine, but comparing displacement and output values with the V1650 (Merlin) and Allison V1710, I'm a bit skeptical of that output.