(Shamelessly stolen from the website atomic rockets)
One notional 1959 concept for a large military Orion was the “doomsday weapon" idea. Instead of one Orion carrying a large number or weapons, able to rain down devastation on many separate targets, the idea was to equip one Orion with one...
Here the Convair "Sky Scorcher" Air-to-Air Missile with a 2 megaton warhead
I have not found any other informations or drawings of this crazy project !