Every anti-drone system seems to have problems:
1) Shotguns: simple and cheap, but max altitude is probably too low
2) Rifles: harder to hit the target especially if it's moving; the bullet, even if it hits the drone, will continue on and come down somewhere
3) Lasers: expensive, possible issues with atmospheric conditions such as fog, smog and smoke
4) Nets: altitude.
5) Hawks/falcons: possibly one-and-done... a bird might be able to attack a drone, but those blades will do it no favors
6) Electronic interference: possible range issues, possibility of disrupting other electronics such as aircraft
I do wonder about the possibility of a man-portable *really* simple SAM system. It need not even be a solid fuel rocket; compressed air/water might be adequate. Perhaps even simple optical tracking, since you will almost always be looking more or less up at the target. No warhead needed; hit to kill would be probably 100% effective *if* you could actually hit the thing.
Simple RC aircraft might work great. Cheap electrically powered plane made out of foam (or inflatable structures), held together with kevlar strings. Break up on hitting the drone, the strings tangle up in the props.