Highly unlikely.
The US has F15Cs and F22s to replace, and F15Cs are literally falling apart.
Pure air dominance at long range. I'm expecting a combat range in excess of 2000nmi, basically twice the range of an F22 or F15.
The F35 is built as a striker. 2x 2000lb bombs and 2x AMRAAMs.
The B21 is built as a long range medium capacity bomber (~24-30klbs, maybe more).
You don't ask either F35 or B21 to go hunting other aircraft.
Not sure, I don't think the NGAD will be an F-15 replacement. Originally the F-22 was supposed to do that, but it was cancelled due to it being more expensive both to procure and operate, leading to an airforce that's less effective dollar-for-dollar than the one that came before it, in cases where the high-end capabilities of the F-22 are not utilized.
Going with an aircraft that's even more expensive than the F-22 would be going in the wrong direction.
The greatly increased range thing also sounds dubious, extra fuel is just pure performance/weight penalty, considering we're entering the range where stealth tanker drones are a thing, it makes less and less sense every day, especially since the Navy NGAD will occupy the long-range niche.
If I would imagine an F-15 replacement, I would think along the lines of the Turkish 5th gen jet - take the F-22 concept, apply major cost savings, and add more range/payload. But I don't think the USAF is going to do that, I think they're thinking in a novel force structure, which might prove itself in practice or not.
From what I gather the NGAD will be, is decidedly not an F-15 replacement, but a blank-cheque aircraft, procured in small numbers, that will demonstrate US technological supremacy and be able to outclass every existing 5th gen aircraft by a healthy margin and give headaches to enemy military planners.